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KMID : 0357919800140020039
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Korean Journal of Pathology
1980 Volume.14 No. 2 p.39 ~ p.44
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A Study on the Influences of Acid-base Imbalance on the Hematological Pictures of the Peripheral Blood, Bone Marrow and Spleen
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Abstract
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The influences of acid-base imbalance on the hematological aspects of peripheral
blood, bone marrow and spleen were studied in albino rats under the controlled
environments including room temperature, diet, fluid supply etc. Acidosis and alkalosis
were induced by intragastric ingestion of ammonium chloride and sodium bicarbonate,
and was confirmed by blood gas analysis including pH and base excess.
The results are summerized as follows :
1) The peripheral blood of the acidosis group showed an increasing tendency in RBC,
Hb, Hct and reticulocyte count comparing to that of control & alkalosis groups. The
WBC total counts were also increased in acidosis group with relative neutrophilia and
lymphopenia while the alkalosis group showed marked relative neutropenia and
lymphocytosis comparing that of acidosis group.
2) In the bone marrow, the acidosis group showed a decreased erythroid series with
increased myeloid series and eosinophilia comparing to the control group. The alkalosis
group showed a marked decrease in erythroid series and a marked increase in lymphoid
cells comparing to those of control and acidosis groups.
3) In the spleen, the acidosis group showed a marked increase in nucleated red blood
cells.
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